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1. Best Slot Machines to Play in 2020. Now that you know the secrets to play slot machines and all the essential slot tips that can help you improve your chances, it's time forone more thing. It's time to look at what are the best slot machines to play in 2020 — if you want to win at slots, of course.
2. With that in mind, the best time to go to the casino to play slots is when the jackpot is high! Of course, the actual time the jackpot is won is completely random and is not based on a certain time of day, date, or month - it is purely down to Lady Luck. Play When the Jackpot Hasn't Been Won for a Long Time.

As far as which day of the week is the best day to visit a casino, I personally have had my best luck on the slot machines on Saturday night after 2 AM (which technically would be Sunday morning.) It is almost.

*sigh*
I doesn't matter what time of day, or day of the week you play.

*sigh*
I doesn't matter what time of day, or day of the week you play.

April 31st from noon to 6pm is when I prefere. Haven't had a losing sesion since I turned 21. ;+)

*sigh*
I doesn't matter what time of day, or day of the week you play.

That's only true under the assumption that the casino doesn't dynamically change their floor on a schedule as the OP said. At least two major gaming manufacturers, IGT and Bally, have systems that allow precisely that to happen -- and at least the Aria is totally set up for that technology. On-the-fly floor mix changes is one of the benefits of server-based gaming. The question is 'if that's implemented, what's the schedule?'.
To my knowledge, most casinos have not implemented server-based gaming in this level of detail. It's still very much a turn-the-key process.

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It is my understanding that even with server-based slots, the casino would have to fax in a report for every machine they change the return on every time they do it. That would be a lot of paperwork to tighten and loosen the slots on a daily and weekly basis.
Even if we ignore that issue, it wouldn't be good business to loosen and tighten slots according to the hour or day. For any given casino there is going to be some optimal return to set the slots at, according to denomination. Same as any other game. Make the machines too tight on a busy night, with a captive audience, and you may make more money temporarily. However, you'll create ill will among all the players who lost, and they will be less likely to return.I'm pretty sure the regulations support, or are being reworked to support, electronic update submissions. It doesn't make sense to have high speed changes on the floor when you can't get them across to the state in high speed.
That said, I'm not sure I agree that it's not good business. It's very commonplace in other industries to charge different fees for the same services at different times. Lunch always costs less than dinner. Even in table games, you can find a $5 table mid-day Thursday but not Saturday evening. Other than changing the game entirely, the two levers the casino has are denom and edge. Most slot games are multi-denom, so that leaves only edge. In my mind, taking a multi-line penny machine from 92% to 90% on a Saturday evening isn't much different than taking a dice table from $5 to $10. Casino games have different EVs based on location, why not time?

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I mean downtown vs. Strip vs. airport. But there's nothing random about which EEPROM goes into which machine. Those are all specifically identified on the floorplan.